CHROMOSOME INSTABILITY AND CANCER

Project One images

Aims of the project

  • Search of CIN associated cancer biomarkers.
  • Analysis of TPX2 non-mitotic functions.
  • Role of Aurora A kinase in cancer development and progression.
  • New anti-tumoral therapies associated with CIN.

 

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CONGENITAL MUSCULAR DISTROPHY ASSOCIATED TO LMNA

Project One images

Aims of the project

  • CRISPR/Cas9 mediated gene therapy: proof of principle and pre-clinical validation
  • Disease modeling: a cKI LMNA R249W mouse model.
  • Testing Mesenchymal cell based therapy in LMNA mouse models.

 

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RARE CANCERS: MECHANISMS AND THERAPIES

Project One images

Aims of the project

  • Modeling: cell lines, canceroids and animal models.
  • Study of the potential of CRISPR/Cas9 mediated gene editing.
  • New, and personalized, therapeutic strategies

 

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Collaborators


 Dr. Jesús García-Donás 


Susana H Boj


Sergio Casas

 



Dra. Maria Jesus Vicent


Dr. Juanfer García
Dra. Gema Moreno
Dr. Ángel Martínez

 


Dr. Lluis Montoliu

 


Dra. Beatriz Martínez-Delgado 
Dra. Pilar Sánchez

 


Dr. Marcos Malumbres
Dra. Mercedes Robledo
Dr. Gonzalo Gómez

 


Dra. Francisca Vicente
Dr. Bastien Cautain

 


Dra. Meritxell Huch