CHROMOSOME INSTABILITY AND CANCER
Aims of the project
- Search of CIN associated cancer biomarkers.
- Analysis of TPX2 non-mitotic functions.
- Role of Aurora A kinase in cancer development and progression.
- New anti-tumoral therapies associated with CIN.
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CONGENITAL MUSCULAR DISTROPHY ASSOCIATED TO LMNA
Aims of the project
- CRISPR/Cas9 mediated gene therapy: proof of principle and pre-clinical validation
- Disease modeling: a cKI LMNA R249W mouse model.
- Testing Mesenchymal cell based therapy in LMNA mouse models.
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RARE CANCERS: MECHANISMS AND THERAPIES
Aims of the project
- Modeling: cell lines, canceroids and animal models.
- Study of the potential of CRISPR/Cas9 mediated gene editing.
- New, and personalized, therapeutic strategies
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Dra. Maria Jesus Vicent
Dr. Juanfer García
Dra. Gema Moreno
Dr. Ángel Martínez
Dr. Lluis Montoliu
Dra. Beatriz Martínez-Delgado
Dra. Pilar Sánchez
Dr. Marcos Malumbres
Dra. Mercedes Robledo
Dr. Gonzalo Gómez
Dra. Francisca Vicente
Dr. Bastien Cautain
Dra. Meritxell Huch
