Publications

  • Blas-Rus N, Bustos E, Pérez de Castro I, de Cárcer G, Malumbres M, Borroto A, Alarcón B, Martín-Cófreces N, Sánchez-Madrid F. Aurora A controls early T cell activation, acting as a checkpoint for signalling-vesicles and tubulin dynamics Nat Commun 2016, 19; 7: 11389. Pubmed
  • Navarro P; Bueno MJ; Zagorac I; Mondejar T; Sánchez J; Mouron S; Muñoz J; Gómez-López G; Jiménez-Renard V; Mulero F; Chandel NS; Quintela-Fandino M. Targeting tumor mitochondrial metabolism overcomes resistance to antiangiogenics. Cell Rep. 2016 Jun 21;15(12):2705-18 IF:8.57 Pubmed
  • González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez A, de Cárcer G, Pérez de Castro I, Earnshaw W, Malumbres M. Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol Cellular Biology 2015, 35:3566-78. Pubmed
  • Shim SY, Pérez de Castro I, Neumayer G, Wang J, Park SK, Sanada K, Nguyen MD. Phosphorylation of TPX2 at threonine 72 in spindle assembly. JCB 2015, 290:9122-34. Pubmed
  • Malumbres M and Pérez de Castro I. Aurora-A: from cancer-associated kinase to promising anti-cancer target. Expert Opin Ther Targets 2014 18(12):1377-93. Pubmed
  • Piazzolla D, Palla AR, Pantoja C, Cañamero M, Pérez de Castro I, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M and Serrano M. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun 2014, 5:4226. Pubmed
  • Epifano C, Megias D, Perez‐Moreno M. p120‐catenin differentially regulates cell migration by Rho‐dependent intracellular and secreted signals. EMBO reports, 2014, 15 (5): 592-600 Pubmed
  • Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proceedings of the National Academy of Sciences, 2014, 111 (31): E3177-E3186 Pubmed
  • Pérez de Castro I*, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, van Dyke T, Malumbres M*. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res 2013, 73: 6804. *Corresponding authorsPubmed
  • Trakala M, Fernández-Miranda G, Hercheen C, Pérez de Castro I, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 2013, 12: 1030-1041. Pubmed
  • Pérez de Castro I*, Malumbres M*. Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2. Genes and Cancer 2012, in press. *Corresponding authors. Pubmed
  • Osei-Sarfo K, Pérez de Castro I, Pellicer A. p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis. Carcinogenesis 2012, 33: 708-713. Pubmed
  • Aguirre-Portolés C, Bird AW, Hyman A, Cañamero M, Pérez de Castro I,* Malumbres M*. Tpx2 controls spindle integrity, genome instability and tumor development in vivo. Cancer Research 2012, 72; 1518. *Corresponding authors. Pubmed
  • Epifano C and Perez-Moreno M. Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell adhesion & migration 2012, 6 (3): 261-273 Pubmed
  • Blas-Rus N, Bustos E, Pérez de Castro I, de Cárcer G, Malumbres M, Borroto A, Alarcón B, Martín-Cófreces N, Sánchez-Madrid F. Aurora A controls early T cell activation, acting as a checkpoint for signalling-vesicles and tubulin dynamics Nat Commun 2016, 19; 7: 11389. Pubmed
  • Navarro P; Bueno MJ; Zagorac I; Mondejar T; Sánchez J; Mouron S; Muñoz J; Gómez-López G; Jiménez-Renard V; Mulero F; Chandel NS; Quintela-Fandino M. Targeting tumor mitochondrial metabolism overcomes resistance to antiangiogenics. Cell Rep. 2016 Jun 21;15(12):2705-18 IF:8.57 Pubmed
  • González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez A, de Cárcer G, Pérez de Castro I, Earnshaw W, Malumbres M. Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol Cellular Biology 2015, 35:3566-78. Pubmed
  • Shim SY, Pérez de Castro I, Neumayer G, Wang J, Park SK, Sanada K, Nguyen MD. Phosphorylation of TPX2 at threonine 72 in spindle assembly. JCB 2015, 290:9122-34. Pubmed
  • Malumbres M and Pérez de Castro I. Aurora-A: from cancer-associated kinase to promising anti-cancer target. Expert Opin Ther Targets 2014 18(12):1377-93. Pubmed
  • Piazzolla D, Palla AR, Pantoja C, Cañamero M, Pérez de Castro I, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M and Serrano M. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun 2014, 5:4226. Pubmed
  • Epifano C, Megias D, Perez‐Moreno M. p120‐catenin differentially regulates cell migration by Rho‐dependent intracellular and secreted signals. EMBO reports, 2014, 15 (5): 592-600 Pubmed
  • Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proceedings of the National Academy of Sciences, 2014, 111 (31): E3177-E3186 Pubmed
  • Pérez de Castro I*, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, van Dyke T, Malumbres M*. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res 2013, 73: 6804. *Corresponding authorsPubmed
  • Trakala M, Fernández-Miranda G, Hercheen C, Pérez de Castro I, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 2013, 12: 1030-1041. Pubmed
  • Pérez de Castro I*, Malumbres M*. Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2. Genes and Cancer 2012, in press. *Corresponding authors. Pubmed
  • Osei-Sarfo K, Pérez de Castro I, Pellicer A. p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis. Carcinogenesis 2012, 33: 708-713. Pubmed
  • Aguirre-Portolés C, Bird AW, Hyman A, Cañamero M, Pérez de Castro I,* Malumbres M*. Tpx2 controls spindle integrity, genome instability and tumor development in vivo. Cancer Research 2012, 72; 1518. *Corresponding authors. Pubmed
  • Epifano C and Perez-Moreno M. Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell adhesion & migration 2012, 6 (3): 261-273 Pubmed