Publications

Gómez-Domínguez, D.; Epifano, C.; de Miguel, F.; Castaño, A.G.; Vilaplana-Martí, B.; Martín, A.; Amarilla-Quintana, S.; Bertrand, A.T.; Bonne, G.; Ramón-Azcón, J.; Rodríguez-Milla, M.A.; Pérez de Castro, I. Consequences of Lmna Exon 4 Mutations in Myoblast Function. Cells 2020, 9, E1286.Pubmed

Segura-Collar B, Gargini R, Tovar-Ambel E, Hérnandez-SanMiguel E, Epifano C, Pérez de Castro I, Hernández-Lain A, Casas-Tintó S, Sánchez-Gómez P. The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas. Cancers (Basel). 2020;12(1):E208.Pubmed

Gómez-Mariano G, Matamala N, Martínez S, Justo I, Marcacuzco A, Jiménez C, Monzón S, Cuesta I, Garfia C, Martínez MT, Huch M, Pérez de Castro I, Posada M, Janciauskiene S, Martínez-Delgado B. Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease. Hepatol Int. 2019;10.1007/s12072-019-10007-y.Pubmed

Pérez de Castro I, Carmena M, Prigent C and Glover DM. Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views. Oncol. 2017, 7:48.Pubmed

Blas-Rus N, Bustos E, Pérez de Castro I, de Cárcer G, Malumbres M, Borroto A, Alarcón B, Martín-Cófreces N, Sánchez-Madrid F. Aurora A controls early T cell activation, acting as a checkpoint for signalling-vesicles and tubulin dynamics Nat Commun 2016, 19; 7: 11389. Pubmed

Navarro P; Bueno MJ; Zagorac I; Mondejar T; Sánchez J; Mouron S; Muñoz J; Gómez-López G; Jiménez-Renard V; Mulero F; Chandel NS; Quintela-Fandino M. Targeting tumor mitochondrial metabolism overcomes resistance to antiangiogenics. Cell Rep. 2016 Jun 21;15(12):2705-18 IF:8.57 Pubmed

González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez A, de Cárcer G, Pérez de Castro I, Earnshaw W, Malumbres M. Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol Cellular Biology 2015, 35:3566-78Pubmed

Shim SY, Pérez de Castro I, Neumayer G, Wang J, Park SK, Sanada K, Nguyen MD. Phosphorylation of TPX2 at threonine 72 in spindle assembly. JCB 2015, 290:9122-34. Pubmed

Malumbres M and Pérez de Castro I. Aurora-A: from cancer-associated kinase to promising anti-cancer target. Expert Opin Ther Targets 2014 18(12):1377-93. Pubmed

Piazzolla D, Palla AR, Pantoja C, Cañamero M, Pérez de Castro I, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M and Serrano M. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun 2014, 5:4226. Pubmed

Epifano C, Megias D, Perez‐Moreno M. p120‐catenin differentially regulates cell migration by Rho‐dependent intracellular and secreted signals. EMBO reports, 2014, 15 (5): 592-600 Pubmed

Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proceedings of the National Academy of Sciences, 2014, 111 (31): E3177-E3186 Pubmed

Pérez de Castro I*, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, van Dyke T, Malumbres M*. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res 2013, 73: 6804. *Corresponding authorsPubmed

Trakala M, Fernández-Miranda G, Hercheen C, Pérez de Castro I, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 2013, 12: 1030-1041. Pubmed

Pérez de Castro I*, Malumbres M*. Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2. Genes and Cancer 2012, in press. *Corresponding authors. Pubmed

Osei-Sarfo K, Pérez de Castro I, Pellicer A. p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis. Carcinogenesis 2012, 33: 708-713. Pubmed

Aguirre-Portolés C, Bird AW, Hyman A, Cañamero M, Pérez de Castro I,* Malumbres M*. Tpx2 controls spindle integrity, genome instability and tumor development in vivo. Cancer Research 2012, 72; 1518. *Corresponding authors. Pubmed

Epifano C and Perez-Moreno M. Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell adhesion & migration 2012, 6 (3): 261-273 Pubmed

Pérez de Castro I*, Aguirre-Portolés C, Martin B, Fernández-Miranda G, Klotzbucher A, Kubbutat M, Megías D, Arlot-Bonnemains Y, Malumbres M*. A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis. Frontiers in Molecular and Cellular Oncology 2011, 1: 50. *Corresponding authors.

Fernández-Miranda G, Trakala M, Martín J, Escobar B, González A, Ghyselinck NB, Ortega S, Cañamero M, Pérez de Castro I, Malumbres M. Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 2011, 138: 2661-72.

Bueno MJ, Gómez de Cedrón M, Gómez-López G, Pérez de Castro I, di Lisio L, Montes S, Martínez N, Guerrero M, Sánchez R, Santos J, Pisano DG, Piris MA, Fernández-Piqueras J, Malumbres M. Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 2011, 117: 6255-66.

Fernández-Miranda G, Pérez de Castro I, Carmena M, Aguirre-Portolés C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres. SUMOylation modulates the function of Aurora-B kinase. J Cell Science 2010, 15: 2823-33.